Design of a solution technique based on an integral approach for the Flexible Open-Flow Shop scheduling problem

In manufacturing industries, scheduling is a form of decision-making that plays a crucial role. The determination of the methods by which a set of jobs must be manufactured in order to seek specific goals leads to the development of different schedule techniques. However, scheduling depends on the type of workshop or manufacturing environment such as open shop, job shop and flow shop. There are cases that more than one environment for the same manufacturing process could coexist. This project deals with a specific scheduling problem in which each job is processed under the combination of two shop environments; the first one is related to an open shop while the second one corresponds to a flow shop; this problem is called the Flexible open-flow shop (FOFS). These types of scheduling problems present NP-hardness, meaning the neediness of sophisticated algorithms to find solutions in reasonable computational times. Additionally, are commonly solved separately or by approximating into another workshop, leaving the interaction of both environments irrelevant. Thus, the main objective of this project is to design solution techniques based on an integral approach to minimize the maximum completion time also known as makespan.Ingeniero (a) IndustrialPregrad

Análisis funcional para la Plataforma IoT PIICO

This paper presents the main challenges of an Internet of Things (IoT) platform. In this sense, an interoperability platform for IoT devices, called PIICO, is presented in the frame of an agriculture application. PIICO is a platform able to resolve interoperability between components and has the potential to be a stable IoT platform. Improvements opportunities of the main IoT PIICO components (nodes, gateway, and data analytics platform) are presented and discussed. The proposed improvements will make that an IoT platform improves its functionality, operation, security, and performance.Este documento presenta los principales desafíos de una plataforma de Internet de las cosas (IoT). En este sentido, se presenta una plataforma de interoperabilidad para dispositivos IoT, denominada PIICO, en el marco de una aplicación agrícola. PIICO es una plataforma capaz de resolver la interoperabilidad entre componentes y tiene el potencial de ser una plataforma de IoT estable. Se presentan y discuten las oportunidades de mejora de los principales componentes de IoT PIICO (nodos, puerta de enlace y plataforma de análisis de datos). Las mejoras propuestas harán que una plataforma IoT mejore su funcionalidad, operación, seguridad y rendimiento

Functional analysis for PIICO IoT platform

Este documento presenta los principales desafíos de una plataforma de Internet de las cosas (IoT). En este sentido, se presenta una plataforma de interoperabilidad para dispositivos IoT, denominada PIICO, en el marco de una aplicación agrícola. PIICO es una plataforma capaz de resolver la interoperabilidad entre componentes y tiene el potencial de ser una plataforma de IoT estable. Se presentan y discuten las oportunidades de mejora de los principales componentes de IoT PIICO (nodos, puerta de enlace y plataforma de análisis de datos). Las mejoras propuestas harán que una plataforma IoT mejore su funcionalidad, operación, seguridad y rendimiento.This paper presents the main challenges of an Internet of Things (IoT) platform. In this sense, an interoperability platform for IoT devices, called PIICO, is presented in the frame of an agriculture application. PIICO is a platform able to resolve interoperability between components and has the potential to be a stable IoT platform. Improvements opportunities of the main IoT PIICO components (nodes, gateway, and data analytics platform) are presented and discussed. The proposed improvements will make that an IoT platform improves its functionality, operation, security, and performance

Peace in crisis: notions, agreement and implementation

Paz en crisis es un proyecto editorial con el que se cierra un programa de investi gación de años atrás y en el que se condensan distintas aproximaciones sobre la paz; en esta oportunidad, bajo la lupa o noción de crisis. Los aportes se encuentran agrupados en 4 tomos, 44 capítulos y 6 bloques temáticos en donde 87 autores ofrecen perspectivas multidisciplinares y multidimensionales, pluralidad meto dológica y variedad en las maneras de hacer investigación y con estilos de escritura diferenciados. Los tomos, en su conjunto, presentan reflexiones diversas sobre las antiguas, múltiples y nuevas conflictividades (tanto armadas como no armadas), así como de los diferentes actores (heredados, emergentes y transformados), en el escenario de lo que ha venido refiriéndose por algunos especialistas como una situación de posacuerdo bélico en Colombia. Este primer tomo, titulado Nociones, acuerdo e implementación (compuesto por trece capítulos y un epílogo), analiza la situación actual de la paz, la democra cia, la seguridad y el ejercicio de los derechos en Colombia, demostrando que lejos de las aspiraciones de estabilización y avance contenidas en los acuerdos, es una renovada y multimodal conflictividad la que define el contexto nacional. En este tomo se apunta a debatir nociones conceptuales y aproximaciones a proble máticas particulares, que resultan relevantes en el marco contextual de crisis que atraviesa la implementación de los acuerdos de paz alcanzados en La Habana. La polarización originada en todos los escenarios de la vida política y social del país como consecuencia del apoyo o rechazo al proceso de paz y sus mecanismos de implementación, ha puesto de manifiesto una profunda crisis de los consensos necesarios, ya no solo para la puesta en marcha de lo acordado en el proceso de paz, sino también de los fundamentos de cohesión que deben hacerse presentes en la elaboración de cualquier proyecto de construcción social amplio, incluyente y sostenible.Peace in crisis is an editorial project that closes a research program gation from years ago and in which different approaches are condensed on the peace; on this occasion, under the magnifying glass or notion of crisis. The contributions are found grouped in 4 volumes, 44 chapters and 6 thematic blocks where 87 authors offer multidisciplinary and multidimensional perspectives, meta plurality dology and variety in the ways of doing research and writing styles differentiated. The volumes, as a whole, present diverse reflections on the ancient, multiple and new conflicts (both armed and unarmed), as well as the different actors (inherited, emerging and transformed), on the stage of what has been referred to by some specialists as a situation of post-war agreement in Colombia. This first volume, entitled Notions, agreement and implementation (composed or thirteen chapters and an epilogue), analyzes the current situation of peace, democracy cia, security and the exercise of rights in Colombia, demonstrating that far from the aspirations of stabilization and progress contained in the agreements, it is a renewed and multimodal conflictivity that defines the national context. In This volume aims to debate conceptual notions and approaches to problems. particular themes, which are relevant in the contextual framework of crisis that is going through the implementation of the peace agreements reached in Havana. The polarization originating in all scenarios of the country's political and social life as a consequence of the support or rejection of the peace process and its mechanisms of implementation, has revealed a deep crisis of consensus necessary, not only for the implementation of what was agreed in the process of peace, but also of the foundations of cohesion that must be present in the development of any broad, inclusive and social construction project sustainable peace, but also of the foundations of cohesion that must be present in the development of any broad, inclusive and social construction project sustainable.Bogot

Biodiversidad en la cuenca del Orinoco. Bases científicas para la identificación de áreas prioritarias para la conservación y uso sostenible de la biodiversidad

Es un placer para el Instituto de Investigación de Recursos Biológicos Alexander von Humboldt presentar a la comunidad científica, conservacionista y autoridades ambientales de Colombia y Venezuela la obra Biodiversidad de la cuenca del Orinoco: bases científicas para la identificación de áreas prioritarias para la conservación y el uso sostenible de la biodiversidad. Este libro es fruto de un esfuerzo de una década de trabajo y recoge numerosos proyectos de carácter institucional que han venido desarrollándose en la Orinoquia, incluyendo el Plan de acción en biodiversidad para la cuenca del Orinoco (2005-2015), además de los resultados de reuniones técnicas de carácter binacional

Revista Temas Agrarios Volumen 26; Suplemento 1 de 2021

1st International and 2nd National Symposium of Agronomic Sciences: The rebirth of the scientific discussion space for the Colombian Agro.1 Simposio Intenacional y 2 Nacional de Ciencias Agronómicas: El renacer del espacio de discusión científica para el Agro colombiano

Correction to: Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

International audienceIn this article, the name of the GLORIA-AF investigator Anastasios Kollias was given incorrectly as Athanasios Kollias in the Acknowledgements. The original article has been corrected

Evolution over Time of Ventilatory Management and Outcome of Patients with Neurologic Disease∗

OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality. DESIGN: Secondary analysis of three prospective, observational, multicenter studies. SETTING: Cohort studies conducted in 2004, 2010, and 2016. PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need for mechanical ventilation. Although volume-cycled ventilation remained the preferred ventilation mode, there was a significant (p < 0.001) increment in the use of pressure support ventilation. The proportion of patients receiving a protective lung ventilation strategy was increased over time: 47% in 2004, 63% in 2010, and 65% in 2016 (p < 0.001), as well as the duration of protective ventilation strategies: 406 days per 1,000 mechanical ventilation days in 2004, 523 days per 1,000 mechanical ventilation days in 2010, and 585 days per 1,000 mechanical ventilation days in 2016 (p < 0.001). There were no differences in the length of stay in the ICU, mortality in the ICU, and mortality in hospital from 2004 to 2016. Independent risk factors for 28-day mortality were age greater than 75 years, Simplified Acute Physiology Score II greater than 50, the occurrence of organ dysfunction within first 48 hours after brain injury, and specific neurologic diseases such as hemorrhagic stroke, ischemic stroke, and brain trauma. CONCLUSIONS: More lung-protective ventilatory strategies have been implemented over years in neurologic patients with no effect on pulmonary complications or on survival. We found several prognostic factors on mortality such as advanced age, the severity of the disease, organ dysfunctions, and the etiology of neurologic disease

Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry

Background: Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospective cohort study. Methods: From the GLORIA-AF Registry Phase II-III (November 2011-December 2014 for Phase II, and January 2014-December 2016 for Phase III), we analysed patients according to their self-reported ethnicity (Asian vs. non-Asian), as well as according to Asian subgroups (Chinese, Japanese, Korean and other Asian). Logistic regression was used to analyse OAC prescription, while the risk of OAC discontinuation and adverse outcomes were analysed through Cox-regression model. Our primary outcome was the composite of all-cause death and major adverse cardiovascular events (MACE). The original studies were registered with ClinicalTrials.gov, NCT01468701, NCT01671007, and NCT01937377. Findings: 34,421 patients were included (70.0 ± 10.5 years, 45.1% females, 6900 (20.0%) Asian: 3829 (55.5%) Chinese, 814 (11.8%) Japanese, 1964 (28.5%) Korean and 293 (4.2%) other Asian). Most of the Asian patients were recruited in Asia (n = 6701, 97.1%), while non-Asian patients were mainly recruited in Europe (n = 15,449, 56.1%) and North America (n = 8378, 30.4%). Compared to non-Asian individuals, prescription of OAC and non-vitamin K antagonist oral anticoagulant (NOAC) was lower in Asian patients (Odds Ratio [OR] and 95% Confidence Intervals (CI): 0.23 [0.22-0.25] and 0.66 [0.61-0.71], respectively), but higher in the Japanese subgroup. Asian ethnicity was also associated with higher risk of OAC discontinuation (Hazard Ratio [HR] and [95% CI]: 1.79 [1.67-1.92]), and lower risk of the primary composite outcome (HR [95% CI]: 0.86 [0.76-0.96]). Among the exploratory secondary outcomes, Asian ethnicity was associated with higher risks of thromboembolism and intracranial haemorrhage, and lower risk of major bleeding. Interpretation: Our results showed that Asian patients with AF showed suboptimal thromboembolic risk management and a specific risk profile of adverse outcomes; these differences may also reflect differences in country-specific factors. Ensuring integrated and appropriate treatment of these patients is crucial to improve their prognosis. Funding: The GLORIA-AF Registry was funded by Boehringer Ingelheim GmbH